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Monday, December 01, 2003  AIDS.org - Plenty of basic information. AIDS - Official Journal of the International AIDS Society. UNAIDS - The Joint United Nations Programme on HIV/AIDS. Divisions of HIV/AIDS Prevention - on the CDC website. The Body - An AIDS and HIV information resource. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. This is a very interesting paper on HIV that appeared in the journal Science in November. For the non-technical minded, a group at Johns Hopkins University characterized the function of the viral protein Vif. This targets the mammalian antiviral pathway by interacting with a couple of proteins to form a complex. The resulting "Vif-Cul5-SCF" complex tags the protein APOBEC3G (which is involved in the antiviral pathway) for degradation so as a result, there is a complete block of the host pathway for clearing a viral infection. (Edited at 8:00 PM - Yeah, I know this is way late, but my mind is totally not working today. And better late than never.) [posted by S. Y. Affolee on 6:23 AM : ]
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